Throughout our history, Women's College Hospital has embarked on numerous research programs relating specifically to women's health. The hospital has claimed numerous "firsts" of which it can be proud, and has pioneered several programs.
| 1947 | Pap Test - Collaborated in the development of the Pap test for detecting early symptoms of cancer, particularly of the cervix |
| 1948 | Cancer Detection Clinic opens - The first of its kind in Ontario - pioneered the practice of screening healthy women for early signs of cancer - renamed Health Watch in 1994 |
| 1963 | Mammography - The first hospital in Ontario to use mammography as a diagnostic tool to detect breast cancer |
| 1971 | Tri-Hospital Diabetes Education Centre (TRIDEC) opens - The first comprehensive teaching program for people with diabetes in Canada |
| 1971 | Perinatal Intensive Care Unit opens - The first in Canada |
| 1973 | Bay Centre for Birth Control opens - The first hospital-supported "walk-in" centre |
| 1976 | Psoriasis Education and Research Centre opens - The first centre in Canada to place emphasis on self-care treatment |
| 1977 | Henrietta Banting Breast Centre opens - A treatment, education and research centre for breast disease |
| 1981 | Perinatal Intensive Care Unit was declared the Regional High-Risk Pregnancy Unit - The first of its kind in Canada |
| 1984 | Sexual Assault Care Centre opens - The first regional centre in Ontario |
| 1987 | Urgent Care Centre opens - The first of its kind in Ontario |
| 1987 | Brief Psychotherapy Centre for Women opens - The first hospital-based therapy program in Canada |
| 1988 | Regional Women's Health Centre opens |
| 1988 | Test-tube quintuplets delivered - The first in Canada |
| 1991 | Ricky Kanee Schachter Dermatology Centre opens - Marks a new era in WCH's leading dermatological research, education and patient care |
| 1991 | U of T Jessie Gray Colorectal Clinic opens - The first of its kind in Toronto |
| 1994 | Osteoporosis Clinic opens - The first multidisciplinary clinic of its kind in Canada |
| 1996 | Women's Cardiovascular Health Initiative established - The first in Canada |
| 1995 | WCH designated as a World Health Organization (WHO) Collaborating Centre in Women's Health - The first in this hemisphere |
| 2000 | Consumer health website www.womenshealthmatters.ca launches |
| 2001 | Response Centre and the 23-Hour Day Unit open |
| 2001 | Women's Pelvic Health Centre launches |
| 2002 | Labyrinth opens - Canada's first and only hospital-based labyrinth |
| 2003 | SARS Assessment Clinic opens (Women's College ACC) - The first in Canada |
| 2005 | The Ontario Ministry of Health and Long-Term Care announces plans to make Women's College Hospital a self-governed institution once more |
| 2006 | Women's Health Matters Forum & Expo celebrates it's 10th year |
| 2006 | Women's College Hospital begins operating independently under the Public Hospitals Act |